ADP-ribosylation site databases | Post-translational modification data analysis
ADP-ribosylation refers to the addition of one or more ADP-ribose units onto proteins post-translationally. This protein modification is often added by ADP-ribosyltransferases, commonly known as PARPs, but it can also be added by other enzymes, including sirtuins or bacterial toxins.
Provides access to experimentally derived information about the human proteome including protein–protein interactions (PPIs), post-translational modifications (PTMs) and tissue expression. HPRD is an integrated knowledgebase for genomic and proteomic investigators. The database also includes (i) PhosphoMotif Finder that contains known kinase/phosphatase substrate and binding motifs, (ii) links to a signaling pathway resource called NetPath, (iii) a distributed annotation system, called Human Proteinpedia for enhanced community participation and allows the use of BLAST for querying mRNA/protein data.
A database of ADP-ribosylated proteins. Each entry of ADPriboDB is annotated manually by at least two independent curators from the literature between January 1975 and July 2015. Over 2300 modified proteins were found in a total of 459 papers. ADPriboDB includes a variety of information for each entry, including any drug treatments performed to obtain the identification of the modification, cell lines and species, the ADP-ribosyltransferases responsible for synthesizing the modification (if known), as well as the site of modification (if identified). Furthermore, the PMID of the journal article, and text citing the figure, table, or supplementary data are included for each entry, enriching every search by allowing the viewer to refer back to the literature and analyze the original data.
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