Drug side effect tools

Discovering the unintended “off-targets” that predict adverse drug reactions (ADRs) is daunting by empirical methods alone. Drugs can act on multiple protein targets, some of which can be unrelated by traditional molecular metrics, and…
CTD
Dataset

CTD Comparative Toxicogenomics Database

Provides information about interactions between environmental chemicals and…

Provides information about interactions between environmental chemicals and gene products and their relationships to diseases. Chemical-gene, chemical-disease and gene-disease interactions manually…

SIDER
Dataset

SIDER Side Effect Resource

Contains information on marketed medicines and their recorded adverse drug…

Contains information on marketed medicines and their recorded adverse drug reactions. The SIDER website enables users to trace drug–side effect pairs to the drug labels: users can navigate to the…

OFFSIDES
Dataset

OFFSIDES

Finds different associations from those reported during clinical trials before…

Finds different associations from those reported during clinical trials before drug approval. The Offsides database is a resource of 438,801 off-label -- those effects not listed on the FDA's…

ADReCS
Dataset

ADReCS Adverse Drug Reaction Classification System

A comprehensive ADR ontology database that provides not only ADR…

A comprehensive ADR ontology database that provides not only ADR standardization but also hierarchical classification of ADR terms. The ADR terms were pre-assigned with unique digital IDs and at the…

CASE-BBB…
Desktop

CASE-BBB prediction

Predicts Blood-Brain-Barrier (BBB) permeability from drug clinical phenotypes…

Predicts Blood-Brain-Barrier (BBB) permeability from drug clinical phenotypes (drug side effects and drug indications). CASE-BBB prediction can apply to both small compounds and macro-molecules…

SEP-L1000
Web

SEP-L1000 Side Effect Prediction based on L1000 data

A machine learning classifier to prioritize adverse drug reactions (ADRs) for…

A machine learning classifier to prioritize adverse drug reactions (ADRs) for approved drugs and pre-clinical small-molecule compounds by combining chemical structure (CS) and gene expression (GE)…

PatchSearch
Desktop

PatchSearch

Implements a local non-sequential searching for similar binding sites on…

Implements a local non-sequential searching for similar binding sites on protein surfaces with a controlled amount of flexibility. PatchSearch is based on an efficient and original quasi-clique…

TarPred
Web

TarPred

An online implementation of a recently published computational model for target…

An online implementation of a recently published computational model for target prediction based on a reference library containing 533 individual targets with 179,807 active ligands. TarPred accepts…

IntSide
Web

IntSide

A web server that integrates chemical and biological information to elucidate…

A web server that integrates chemical and biological information to elucidate the molecular mechanisms underlying drug side effects. IntSide currently catalogs 1175 side effects caused by 996 drugs,…

FragmentStore
Dataset

FragmentStore

A resource for the comparison of fragments found in metabolites, drugs or toxic…

A resource for the comparison of fragments found in metabolites, drugs or toxic compounds. Starting from 13,000 metabolites, 16,000 drugs and 2200 toxic compounds we generated 35,000 different…

SePreSA
Web

SePreSA

A server for the prediction of population susceptible to serious adverse drug…

A server for the prediction of population susceptible to serious adverse drug reaction.

ToxReporter
Desktop

ToxReporter

Compiles information from a broad selection of resources and limits display of…

Compiles information from a broad selection of resources and limits display of the information to user-selected areas of interest. ToxReporter is a PERL-based web-application which utilizes a MySQL…

HLA-ADR
Dataset

HLA-ADR The HLA and Adverse Drug Reaction Database

An open database listing known adverse drug reactions with Human leukocyte…

An open database listing known adverse drug reactions with Human leukocyte antigens (HLA) alleles. The HLA-ADR has been implemented within the wider Allele Frequency Net Database (AFND), which stores…

Label…
Algorithm

Label propagation algorithm

An integrative label propagation framework to predict drug-drug interaction…

An integrative label propagation framework to predict drug-drug interaction (DDI) by integrating label side effects, off-label side effects, and chemical structures. A systematic comparison of the…

DR. PRODIS
Web

DR. PRODIS DRugome, PROteome, and DISeasome

A comprehensive proteome scale approach that predicts human protein targets and…

A comprehensive proteome scale approach that predicts human protein targets and side effects of drugs. We develop a comprehensive proteome scale approach that predicts human protein targets and side…

DITOP
Dataset

DITOP Drug-Induced Toxicity Related Proteins

A database that is intending to provide comprehensive information of…

A database that is intending to provide comprehensive information of drug-induced toxicity related proteins.

ToxAlerts
Dataset

ToxAlerts

A Web-based platform for collecting and storing toxicological structural alerts…

A Web-based platform for collecting and storing toxicological structural alerts from literature and for virtual screening of chemical libraries to flag potentially toxic chemicals and compounds that…

MetaADEDB
Dataset

MetaADEDB

Provides a useful tool to search for known side effects or predict potential…

Provides a useful tool to search for known side effects or predict potential side effects for a given drug or compound.

HLADR
Dataset

HLADR Human Leukocyte Antigen-Adverse Drug Reaction

Provides dedicated information for associations between Human Leukocyte…

Provides dedicated information for associations between Human Leukocyte Antigens (HLA) and Adverse Drug Reactions (ADR). HLADR is a pharmacogenomics database. Each database entry is a 2 by 2…

MedDRA
Dataset

MedDRA

A rich and highly specific standardised medical terminology to facilitate…

A rich and highly specific standardised medical terminology to facilitate sharing of regulatory information internationally for medical products used by humans. ICH’s powerful tool, MedDRA is…

WHO-ART
Dataset

WHO-ART WHO Adverse Reaction Terminology

This is a highly refined terminology for coding clinical information in…

This is a highly refined terminology for coding clinical information in relation to drug therapy. WHO-ART covers most medical terms needed in adverse reaction reporting, but is still small enough to…

Datinrad
Dataset

Datinrad Database Information Radiopharmaceuticals

An application for easily managing a database with information on interactions…

An application for easily managing a database with information on interactions of drugs with radiopharmaceuticals and adverse effects of radiopharmaceuticals.

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