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SIDER / Side Effect Resource
Contains information on marketed medicines and their recorded adverse drug reactions. The SIDER website enables users to trace drug–side effect pairs to the drug labels: users can navigate to the drug's page and click on the side effect of interest. On the presented drug label, all instances of the side effect are marked. In this way, users can quickly trace the origin of an extracted side effect in order to rule out false positives. The complete data set of side effects and the data set of indications are available for download from the SIDER website in text format, including PubChem and MedDRA identifiers.
ADReCS / Adverse Drug Reaction Classification System
A comprehensive ADR ontology database that provides not only ADR standardization but also hierarchical classification of ADR terms. The ADR terms were pre-assigned with unique digital IDs and at the same time were well organized into a four-level ADR hierarchy tree for building an ADR-ADR relation. In summary, ADReCS offers an opportunity for direct computation on ADR terms and also provides clues to mining common features underlying ADRs.
A Web-based platform for collecting and storing toxicological structural alerts from literature and for virtual screening of chemical libraries to flag potentially toxic chemicals and compounds that can cause adverse side effects. An alert is uniquely identified by a SMARTS template, a toxicological endpoint, and a publication where the alert was described. Additionally, the system allows storing complementary information such as name, comments, and mechanism of action, as well as other data.
ECG-ViEW / Electrocardiogram Vigilance with Electronic data Warehouse
Contains all diagnoses, drug prescriptions, and selected laboratory test results that can affect an electrocardiograpm (ECG). ECG-ViEW is a downloadable database that provides an opportunity to evaluate the effects of a drug or combination of drugs, on electrophysiological changes in patients with many diseases and drug treatments. It also contains ECG data from healthy people, for possible use as a reference cohort of the general South Korean population. This resource could be an excellent data source for research scientists who study electrophysiological effect of diseases or drug prescription.
LIDPD / Levodopa-Induced Dyskinesia in Parkinson's Disease
Summarizes literature-curated information on levodopa-induced dyskinesia (LID) genetics. LIPDP is a publicly available web resource that investigates the LID-associated genes in a broader functional context through analysis of their relationships based on network models. It uses different underlying networks and allows to incorporate data into the analyses. The core of LIDPD is a set of Panel genes that have been associated with LID in the scientific literature. Different Highlight datasets provide additional gene annotations or associations with Parkinson's disease.
Cadec / CSIRO Adverse Drug Event Corpus
Allows the consulting of an annotated corpus of medical forum posts on patient reported Adverse Drug Events (ADE). Cadec is composed of medication consumer posts from AskaPatient, a medical forum. These posts are annotated with concepts such as drug names, diseases, adverse reactions and symptoms. All of these concepts are linked to their corresponding concepts in controlled vocabularies. This database provides opportunities for researchers of text mining for pharmacovigilance.
HLA-ADR / The HLA and Adverse Drug Reaction Database
An open database listing known adverse drug reactions with Human leukocyte antigens (HLA) alleles. The HLA-ADR has been implemented within the wider Allele Frequency Net Database (AFND), which stores large collections of data on the allele and haplotype frequencies for healthy, worldwide populations, as well as modules for exploring immunogenetic disease associations. HLA-ADR provides a resource that not only facilitates meta-analyses but also enables users to further their investigations by using resources available with the main AFND website, e.g. on the incidence of particular HLA alleles/haplotypes in healthy worldwide populations.
HLADR / Human Leukocyte Antigen-Adverse Drug Reaction
Provides dedicated information for associations between Human Leukocyte Antigens (HLA) and Adverse Drug Reactions (ADR). HLADR is a pharmacogenomics database. Each database entry is a 2 by 2 contingency table on which performance metrics (such as p value, odds ratio, sensitivity, specificity, positive predictive value, and negative predictive value) were calculated in a consistent manner for different drug-HLA pairs. Therefore, the results from multiple studies could be compared in terms of different performance perspectives for a given HLA allele to serve as a safety biomarker against an ADR induced by the drug.
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