|Application:||Gene expression microarray analysis|
|Number of samples:||9|
|Release date:||Jul 11 2009|
|Last update date:||May 4 2018|
|Diseases:||Murine Acquired Immunodeficiency Syndrome|
|Dataset link||Parasite strain-specific pathogenesis in murine infections with Trypanosoma brucei|
Mouse spleens were dissected from infected or uninfected mice 10 days post infection, when the differences in pathology criteria (hepatomegaly, red blood cell numbers, reticulocyte percentage, IL10, IFNg and Il12 levels, and splenomegaly) were the greatest. This allowed a three-way comparison, uninfected vs 247-infected, uninfected vs 927-infected, and 247-infected vs 927-infected, allowing us to analyse genes that are differentially expressed between infected and uninfected spleens, but also crucially allows the differentiation between host gene expression with pathogenic (927) and less pathogenic (247) trypanosome strains.