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AGGRESCAN specifications


Unique identifier OMICS_03858
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes

Publications for AGGRESCAN

AGGRESCAN citations


Folding mechanisms steer the amyloid fibril formation propensity of highly homologous proteins† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc00166a

PMCID: 5933289
PMID: 29780459
DOI: 10.1039/c8sc00166a

[…] The analysis of Ros87, Ml452–151 and Ml153–149 sequences performed using the server AGGRESCAN reveals that the stretch of amino acids encompassing the regions His76–Cys82 in Ros87, corresponding to Pro72–Asp79 in Ml153–149 and Pro74–Glu81 in Ml452–151 (Fig. SI5), are sequences with h […]


Using extensional flow to reveal diverse aggregation landscapes for three IgG1 molecules

Biotechnol Bioeng
PMCID: 5900942
PMID: 29315487
DOI: 10.1002/bit.26543

[…] Tiller & Tessier, ; van der Kant et al., ). In silico analyses, such as TANGO (Fernandez‐Escamilla, Rousseau, Schymkowitz, & Serrano, ), Zyggregator (Tartaglia & Vendruscolo, ), Waltz (Oliveberg, ), Aggrescan (Conchillo‐Solé et al., ), and PASTA (Trovato, Seno, & Tosatto, ) can be used to predict the presence of aggregation‐prone regions (APRs) within proteins using protein primary sequence infor […]


Towards an experimental classification system for membrane active peptides

Sci Rep
PMCID: 5775428
PMID: 29352252
DOI: 10.1038/s41598-018-19566-w

[…] The net charge, molecular mass, average hydrophobicity, hydrophobic moment, aggregation potential (Na4vSS property of the the AggreScan algorithm) and peptide secondary structure (according to the GOR IV algorithm) were calculated for each molecule using an add-on for the software Kamal v1.0 alpha. The TM scale was employed […]


Engineering of Fc Fragments with Optimized Physicochemical Properties Implying Improvement of Clinical Potentials for Fc Based Therapeutics

Front Immunol
PMCID: 5766897
PMID: 29375551
DOI: 10.3389/fimmu.2017.01860

[…] ational introduction of proper hydrophilic amino acids for disruption of the large hydrophobic aggregation-prone clusters. In addition to SAP (–), several online programs such as TANGO (–), PASTA (), AGGRESCAN (), and Aggrescan3D () are also widely used to predict aggregation-prone regions within proteins. Therefore, it is desired that new Ig variants could be identified in the future.In many inst […]


A single cysteine post translational oxidation suffices to compromise globular proteins kinetic stability and promote amyloid formation

Redox Biol
PMCID: 5684091
PMID: 29132128
DOI: 10.1016/j.redox.2017.10.022

[…] the human apoptosis regulator Bcl-xL are predicted to be highly destabilized, with ΔΔG values of 4.57 and 6.38 kcal/mol, respectively.Fig. 7Fig. 7The sequence-based aggregation prediction algorithms AGGRESCAN and Zyggregator were used to assess if Asp, and by analogy CySO3H, might act creating new or stronger “hot spots” that favours the aggregation in the oxidized FF domain. No significant cha […]


Characterization of Soft Amyloid Cores in Human Prion Like Proteins

Sci Rep
PMCID: 5608858
PMID: 28935930
DOI: 10.1038/s41598-017-09714-z

[…] sly identified by PAPA, in all the above described proteins (Figs  to ).The predicted soft amyloid cores for these proteins are shown in Table . Remarkably, well-validated aggregation predictors like Aggrescan, Tango and Zyggregator failed to classify these stretches as aggregation-prone, the exception being the PHC1 core, which was identified by Tango (Table ). The underlying reason explaining wh […]


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AGGRESCAN institution(s)
Department de Bioquímica i Biologia Molecular and Institut de Biotecnologia i de Biomedicina, Universitat Autónoma de Barcelona, Barcelona, Spain


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