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AGGRESCAN specifications


Unique identifier OMICS_03858
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes

Publications for AGGRESCAN

AGGRESCAN citations


Using extensional flow to reveal diverse aggregation landscapes for three IgG1 molecules

Biotechnol Bioeng
PMCID: 5900942
PMID: 29315487
DOI: 10.1002/bit.26543

[…] tessier, ; van der kant et al., ). in silico analyses, such as tango (fernandez‐escamilla, rousseau, schymkowitz, & serrano, ), zyggregator (tartaglia & vendruscolo, ), waltz (oliveberg, ), aggrescan (conchillo‐solé et al., ), and pasta (trovato, seno, & tosatto, ) can be used to predict the presence of aggregation‐prone regions (aprs) within proteins using protein primary sequence […]


Towards an experimental classification system for membrane active peptides

Sci Rep
PMCID: 5775428
PMID: 29352252
DOI: 10.1038/s41598-018-19566-w

[…] material ). forty-eight peptides were analyzed, after removal of duplicate cases to prevent biases. the residue number, molecular mass, net charge, aggregation potential (na4vss parameter of the aggrescan algorithm), hydrophobicity (transmembrane tendency (tm) scale), hydrophobic moment (using the tm scale) and secondary structure according to the gor iv algorithm (which considers helical, […]


Engineering of Fc Fragments with Optimized Physicochemical Properties Implying Improvement of Clinical Potentials for Fc Based Therapeutics

Front Immunol
PMCID: 5766897
PMID: 29375551
DOI: 10.3389/fimmu.2017.01860

[…] introduction of proper hydrophilic amino acids for disruption of the large hydrophobic aggregation-prone clusters. in addition to sap (–), several online programs such as tango (–), pasta (), aggrescan (), and aggrescan3d () are also widely used to predict aggregation-prone regions within proteins. therefore, it is desired that new ig variants could be identified in the future., in many […]


A single cysteine post translational oxidation suffices to compromise globular proteins kinetic stability and promote amyloid formation

Redox Biol
PMCID: 5684091
PMID: 29132128
DOI: 10.1016/j.redox.2017.10.022

[…] human apoptosis regulator bcl-xl are predicted to be highly destabilized, with δδg values of 4.57 and 6.38 kcal/mol, respectively.fig. 7fig. 7, the sequence-based aggregation prediction algorithms aggrescan and zyggregator were used to assess if asp, and by analogy cyso3h, might act creating new or stronger “hot spots” that favours the aggregation in the oxidized ff domain. no significant […]


Characterization of Soft Amyloid Cores in Human Prion Like Proteins

Sci Rep
PMCID: 5608858
PMID: 28935930
DOI: 10.1038/s41598-017-09714-z

[…] identified by papa, in all the above described proteins (figs  to )., the predicted soft amyloid cores for these proteins are shown in table . remarkably, well-validated aggregation predictors like aggrescan, tango and zyggregator failed to classify these stretches as aggregation-prone, the exception being the phc1 core, which was identified by tango (table ). the underlying reason explaining […]


Rational identification of aggregation hotspots based on secondary structure and amino acid hydrophobicity

Sci Rep
PMCID: 5573320
PMID: 28842596
DOI: 10.1038/s41598-017-09749-2

[…] by introducing dozens of mutations simultaneously, based on the results of multiple sequence alignment (msa) and structural data, . in addition, hotspots can be predicted using software such as aggrescan, solubis, and camsol., for such difficult cases, learning from successful examples in previous research would facilitate development of a new method of estimation. in a previous study, […]

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AGGRESCAN institution(s)
Department de Bioquímica i Biologia Molecular and Institut de Biotecnologia i de Biomedicina, Universitat Autónoma de Barcelona, Barcelona, Spain


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