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Align-GVGD

A method that combines Grantham Variation (GV) and Grantham Deviation (GD) scores to predict the transactivation activity of each missense substitution. We compared our predictions against experimentally measured transactivation activity (yeast assays) to evaluate their accuracy. Finally, the prediction results were compared with those obtained by the program Sorting Intolerant from Tolerant (SIFT) and Dayhoff's classification.

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Align-GVGD classification

  • Animals
    • Homo sapiens

Align-GVGD specifications

Interface:
Web user interface
Input data:
List of mutations, MSA
Programming languages:
Perl
Stability:
Stable
Restrictions to use:
None
Input format:
Text, FASTA
Computer skills:
Basic
Maintained:
Yes

Align-GVGD support

Maintainer

  • Sean V. Tavtigian <>

Credits

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Publications

Institution(s)

International Agency for Research on Cancer Lyon, France; Department of Bioinformatics and Computational Biology, George Mason University Manassas, VA, USA; Department of Clinical Oncology, Institute of Development Aging and Cancer, Tohoku University Sendai, Japan

Link to literature

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