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A method that combines Grantham Variation (GV) and Grantham Deviation (GD) scores to predict the transactivation activity of each missense substitution. We compared our predictions against experimentally measured transactivation activity (yeast assays) to evaluate their accuracy. Finally, the prediction results were compared with those obtained by the program Sorting Intolerant from Tolerant (SIFT) and Dayhoff’s classification.

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  • Sean V. Tavtigian <sean.tavtigian at hci.utah.edu>


International Agency for Research on Cancer Lyon, France; Department of Bioinformatics and Computational Biology, George Mason University Manassas, VA, USA; Department of Clinical Oncology, Institute of Development Aging and Cancer, Tohoku University Sendai 980-8575, Japan

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  • Animals
    • Homo sapiens
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