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The phenomenon of cross-reactivity between allergenic proteins plays an important role to understand how the immune system recognizes different antigen proteins. Allergen proteins are known to cross-react if their sequence comparison shows a high sequence identity which also implies that the proteins have a similar 3D fold.
(Negi and Braun, 2017) Cross-React: a new structural bioinformatics method for predicting allergen cross-reactivity. Bioinformatics.