Allergen databases | Immunology system data analysis
Increasingly regulators are demanding evaluation of potential allergenicity of foods prior to marketing. Primary risks are the transfer of allergens or potentially cross-reactive proteins into new foods.
A web server that provides rapid, cross-referenced access to the sequences, structures and IgE epitopes of allergenic proteins. SDAP contains information about the allergen name, source, sequence, structure, IgE epitopes and literature references and easy links to the major protein (PDB, SWISS-PROT/TrEMBL, PIR-ALN, NCBI Taxonomy Browser) and literature (PubMed, MEDLINE) on-line servers. The computational component in SDAP uses an original algorithm based on conserved properties of amino acid side chains to identify regions of known allergens similar to user supplied peptides or selected from the SDAP database of IgE epitopes. This and other bioinformatics tools can be used to rapidly determine potential cross-reactivities between allergens and to screen novel proteins for the presence of IgE epitopes they may share with known allergens.
Provides information to classify allergens into protein families. AllFam gathers about 1042 allergens shared in 151 families. The database can provide lists of allergen families filtered by source and route of exposure. Moreover, the database contains a list of allergens and an allergen family fact sheet with information on biochemical properties and the allergologic significance of its allergenic members for each family.
Provides information about allergens and allergen related features like IgE-binding epitopes, IgE antibodies and cross-reactivity. AllerBase numbers about 2388 allergens including WHO/IUIS Allergen Nomenclature Sub-committee recognized allergens and experimentally validated allergens from various sources like plants, animals or fungi. Each allergen is represented by nine informative allergen attributes.
Aims to furnish information for the evaluation of potential allergenicity of new food proteins produced by genetically modified organisms (GMO) and novel protein ingredients in processed foods. AllergenOnline includes about 2035 sequences from 808 taxonomic-protein groups, annually updated to identify proteins that may require additional tests.
An integrated web-based system providing information about allergen in foods, microorganisms, animals and plants. AllergenPro has the three main features namely, (1) allergen list with epitopes, (2) searching of allergen using keyword, and (3) methods for allergenicity prediction. AllergenPro outputs the search based allergen information through a user-friendly web interface, and users can run tools for allergenicity prediction using three different methods namely, (1) FAO/WHO, (2) motif-based and (3) epitope-based methods.
Gathers information about all allergens and isoforms that are recognized by the International Union of Immunological Societies (IUIS) Allergen Nomenclature Sub-Committee. WHO/IUIS contains allergen sequences, Protein Database numbers, and information on structural features related to allergenicity for a given allergen classified by using a systematic nomenclature based on the Linnean system.
A database to collect in a single web-based resource basic and clinical information, and data about any allergenic organism and its molecular structures capable to induce an IgE-mediated disease. Allergome main goal is to collect a list of allergenic sources and molecules by using the widest selection criteria and sources. A further development of the Allergome platform has been represented by the Real Time Monitoring of IgE sensitization module (ReTiME) that allows uploading of raw data from both in vivo and in vitro testing, thus representing the first attempt to have IT applied to allergy data mining.