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Protocols

AllerTOP specifications

Information


Unique identifier OMICS_12404
Name AllerTOP
Interface Web user interface
Restrictions to use None
Input data Protein sequence
Input format Plain text (one letter code)
Computer skills Basic
Version 2.0
Stability Stable
Maintained Yes

Maintainer


  • person_outline Irini Doytchinova

Publications for AllerTOP

AllerTOP citations

 (6)
call_split

Novel Immunoinformatics Approaches to Design Multi epitope Subunit Vaccine for Malaria by Investigating Anopheles Salivary Protein

2018
Sci Rep
PMCID: 5773588
PMID: 29348555
DOI: 10.1038/s41598-018-19456-1
call_split See protocol

[…] he potential of a material to cause sensitization and allergic reactions associated with the IgE antibody response. Therefore, the predicted vaccine construct must be free from the allergenic nature. AllerTOP v. 2.0 was used to check the allergenicity of the vaccine construct based on the method that uses auto cross-covariance (ACC) transformation of protein sequences into uniform equal-length vec […]

library_books

Predicted Release and Analysis of Novel ACE I, Renin, and DPP IV Inhibitory Peptides from Common Oat (Avena sativa) Protein Hydrolysates Using in Silico Analysis

2017
PMCID: 5742776
PMID: 29207547
DOI: 10.3390/foods6120108

[…] > 2), and trypsin. Toxicity was scanned with default settings using ToxinPred, which is available at http://www.imtech.res.in/raghava/toxinpred/multi_submit.php []. Allergenicity was predicted using AllerTOP, which is available at http://www.pharmfac.net/allertop/ [] (). […]

call_split

Comprehensive in silico allergenicity assessment of novel protein engineered chimeric Cry proteins for safe deployment in crops

2017
BMC Biotechnol
PMCID: 5541426
PMID: 28768539
DOI: 10.1186/s12896-017-0384-z
call_split See protocol

[…] AllerTop (www.pharmfac.net/allertop) [] is another web based server that was used in the study for validation of the chimeric proteins. It is an alignment-free server that predicts allergenicity of pr […]

library_books

Enzyme Assisted Discovery of Antioxidant Peptides from Edible Marine Invertebrates: A Review

2017
Mar Drugs
PMCID: 5334622
PMID: 28212329
DOI: 10.3390/md15020042

[…] assessed in silico for toxicity and allergenicity []. Potential toxicity was predicted using the ToxinPred web server []. Potential allergenicity of the peptides was assessed by using AlgPred [] and AllerTOP []. In silico analyses predicted that all the peptides were non-toxic, although 564 peptides were predicted to be potential allergens. Such a large-scale screening of peptides for toxicity an […]

library_books

In silico proposition to predict cluster of B and T cell epitopes for the usefulness of vaccine design from invasive, virulent and membrane associated proteins of C. jejuni

2016
PMCID: 4932005
PMID: 27376537
DOI: 10.1186/s40203-016-0020-y

[…] respectively from FlaA, MOMP, PEB3, CadF proteins were capable of inducing the desired immune response as B cell epitope. Among them “EINKN” and “LDENGCE” were also found non-allergen as predicted by AllerTOP 1.0 tool.For T cell epitope prediction, plenty of algorithms are freely available and in this study we employed IEDB analysis tool which is possibly the most wide-ranging database offering se […]

library_books

T cell epitope vaccine design by immunoinformatics

2013
Open Biol
PMCID: 3603454
PMID: 23303307
DOI: 10.1098/rsob.120139

[…] authors thank their colleagues from the Faculty of Pharmacy, the Medical University of Sofia—Ivan Dimitrov, Mariyana Atanasova and Panaiot Garnev—for their contributions in the developing of EpiTOP, AllerTOP and EpiDOCK. I.D. thanks her former colleagues from the Jenner Institute, Oxford University—Darren R. Flower, Pigping Guan, Channa Hattotuwagama and Martin Blythe—for their contributions in t […]

Citations

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AllerTOP institution(s)
Faculty of Pharmacy, Medical University of Sofia, Sofia, Bulgaria; Bangov Faculty of Natural Sciences, Konstantin Preslavski Shumen University, Shumen, Bulgaria; Life and Health Sciences, Aston University, Aston Triangle, Birmingham, UK
AllerTOP funding source(s)
We acknowledge the Bulgarian Science Fund for financial support (Grants DCVNP 02-1/2009 and IO1/7).

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