An integrative database for gene dysregulation in Alzheimer's disease. AlzBase collects several categories of information, including (1) gene dysregulation in AD and closely related processes/diseases such as aging and neurological disorders, (2) correlation of gene dysregulation with AD severity, (3) a wealth of annotations on the functional and regulatory information, and (4) network connections for gene-gene relationship. In addition, AlzBase also provided a comprehensive summary for the top ranked genes. By evaluating the information curated in AlzBase, researchers can prioritize genes from their own research and generate novel hypothesis regarding the molecular mechanism of AD. To demonstrate the utility of AlzBase, the genes from the genetic studies of AD were examined and it revealed links between the upstream genetic variations and downstream endo-phenotype and suggested several genes with higher priority.
CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China; Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China
AlzBase funding source(s)
This work was supported by the grants from the National Basic Research Program of China (973 Program, Grant No. 2014CB964901) and National High Technology Research and Development Program (863 Program, Grant No. 2015AA020100) awarded to HL from the Ministry of Science and Technology of China.