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AlzGene specifications


Unique identifier OMICS_03996
Name AlzGene
Restrictions to use None
Maintained Yes


  • Primates
    • Homo sapiens

Publication for AlzGene

AlzGene citations


Rare ABCA7 variants in 2 German families with Alzheimer disease

PMCID: 5863691
PMID: 29577078
DOI: 10.1212/NXG.0000000000000224

[…] or mutated at highly conserved positions (GERP_RS>3). All annotations were derived from dbNSFP3.0a. We further used a list of AD candidate genes that was collected from various GWAS in the dbGAP, the Alzgene database, and the Genotator tool to prioritize variants. […]


Autophagy and Alzheimer’s Disease: From Molecular Mechanisms to Therapeutic Implications

PMCID: 5797541
PMID: 29441009
DOI: 10.3389/fnagi.2018.00004

[…] Gene Ontology term “autophagy” (GO:0006914, Homo sapiens) or in KEGG Pathway () “autophagy-animal” (ko04140), and (2) genes involved in AD, defined as being included either in databases AlzBase () or AlzGene (), or related to AD as shown by the text-mining tool GLAD4U (). AlzBase provides data on “gene dysregulation in AD and closely related processes/diseases such as aging and neurological disord […]


Molecular and functional signatures in a novel Alzheimer’s disease mouse model assessed by quantitative proteomics

Mol Neurodegener
PMCID: 5771139
PMID: 29338754
DOI: 10.1186/s13024-017-0234-4

[…] c platform allowed us to discover in-depth proteome which dynamic range covered over six orders of magnitude. This comprehensive dataset included a number of well-known risk factors of AD (, such as Apoe [], Clu [], and TDP-43 (Tardbp) [, ], which were quantified in all samples. Notably, we also detected low-abundance risk factors, such as Gab2 [–], Trem2 [], and Abca7 [], i […]


Integrative Analysis to Identify Common Genetic Markers of Metabolic Syndrome, Dementia, and Diabetes

PMCID: 5737114
PMID: 29229897
DOI: 10.12659/MSM.905521

[…] enes, three candidate genes (APOE, IGF1R, and CCR5) were previously known for their association with neurodegenerative disorder including Alzheimer disease, as shown by meta-analysis results from the AlzGene database (). The APOE polymorphism showed modest association with Alzheimer disease. Most importantly, the directionality of effects of the variants on Alzheimer disease was generally consiste […]


An analysis of disease gene relationship from Medline abstracts by DigSee

Sci Rep
PMCID: 5215527
PMID: 28054646
DOI: 10.1038/srep40154

[…] e than 90% of the top 500 genes were correctly identified, only 55% of genes ranked between 2000 and 2500 were related to Alzheimer’s disease. We compared genes identified by DigSee with 656 genes in AlzGene, an Alzheimer’s disease database, which collected comprehensive information about genes related to Alzheimer’s disease from genetic association studies. shows that 415 genes were shared betwe […]


The ALFA project: A research platform to identify early pathophysiological features of Alzheimer's disease

PMCID: 5644283
PMID: 29067295
DOI: 10.1016/j.trci.2016.02.003
call_split See protocol

[…] odness of fit test was used to assess for statically significant differences between the frequencies of the APOE genotypes between the parent ALFA cohort and those reported in control subjects in the AlzGene database ( The same test (chi square) was used to assess for significant differences in the prevalence of clinical features and midlife CAIDE dementi […]


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AlzGene institution(s)
Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease (MIND), Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA

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