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Amino acid mutation identification software tools | Mass spectrometry-based untargeted proteomics

Amino acid mutations in proteins can be found by searching tandem mass spectra acquired in shotgun proteomics experiments against protein sequences predicted from genomes. Traditionally, unconstrained searches for amino acid mutations have been accomplished by using a sequence tagging approach that combines de novo sequencing with database searching.

Source text:
(Hyatt and Pan 2012) Exhaustive database searching for amino acid mutations in proteomes. Bioinformatics.

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