Aminode specifications


Unique identifier OMICS_32014
Name Aminode
Interface Web user interface
Restrictions to use None
Input data The amino acid sequences of the protein homologs, and a phylogenetic tree that describes the evolutionary relationships of the inputted protein homologs.
Computer skills Basic
Stability Stable
Maintained Yes


  • person_outline Marco Sardiello

Publication for Aminode

Aminode citation


Aminode: Identification of Evolutionary Constraints in the Human Proteome

Sci Rep
PMCID: 5778061
PMID: 29358731
DOI: 10.1038/s41598-018-19744-w

[…] onservation at sites crucial to structure and function of the protein. Thus, from such observed evolutionary constraints one may deduce and predict the relative importance of specific protein sites–. Aminode enables the execution of complex sequence analyses in order to identify protein regions that are either evolutionarily constrained or unconstrained. The Aminode webtool allows researchers the […]

Aminode institution(s)
Department of Molecular and Human Genetics, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, TX, USA
Aminode funding source(s)
Supported by NIH grant NS079618 and by a grant from the Beyond Batten Disease Foundation.

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