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AnEnPi specifications


Unique identifier OMICS_22396
Name AnEnPi
Alternative name Analogous Enzyme Pipeline
Interface Web user interface
Restrictions to use Academic or non-commercial use
Programming languages Perl
Computer skills Basic
Stability No
Maintained No


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Publication for Analogous Enzyme Pipeline

AnEnPi citations


Functional Analogy in Human Metabolism: Enzymes with Different Biological Roles or Functional Redundancy?

Genome Biol Evol
PMCID: 5737724
PMID: 28854631
DOI: 10.1093/gbe/evx119

[…] ly relevant) biological roles.To catalog the repertoire of isofunctional enzymes cooccurring in the human metabolism (from now on referred as intragenomic analogous enzymes) a computational pipeline (AnEnPi) () was employed to identify putative analogous enzymes using the KEGG database () as the source of information. The predicted functional analogy instances were confirmed based on domain, foldi […]


A Computational Methodology to Overcome the Challenges Associated With the Search for Specific Enzyme Targets to Develop Drugs Against Leishmania major

Bioinform Biol Insights
PMCID: 5470852
PMID: 28638238
DOI: 10.1177/1177932217712471

[…] e complete sets of (1) 8265 sequences of L major with 1547 that are annotated with ECs (341 nr ECs) and (2) 20 834 sequences of H sapiens with 6599 that are annotated with ECs (384 nr ECs) from KEGG, AnEnPi released a list of 67 protein sequences corresponding to 42 enzymatic activities that were putatively specific to L major compared with humans.From the 67 enzymes (42 ECs) released by AnEnPi, 1 […]

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AnEnPi institution(s)
Laboratory for Functional Genomics and Bioinformatics, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil; Ataulpho de Paiva Foundation, Rio de Janeiro, Brazil
AnEnPi funding source(s)
Supported by CNPq, CAPES, FAPERJ, the World Community Grid, the Bioinformatics Platform PDTIS/Fiocruz and Fiocruz/PAPES.

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