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Number of citations per year for the bioinformatics software tool ANOSVA

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ANOSVA specifications


Unique identifier OMICS_07625
Alternative name ANalysis Of Splice VAriation
Software type Application/Script
Interface Command line interface
Restrictions to use None
Biological technology Affymetrix
Operating system Unix/Linux
Computer skills Advanced
Stability Stable
Maintained Yes


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  • person_outline Melissa Cline

Publication for ANalysis Of Splice VAriation

ANOSVA citations


Alternative transcription of a shorter, non anti angiogenic thrombospondin 2 variant in cancer associated blood vessels

PMCID: 5945577
PMID: 29467494
DOI: 10.1038/s41388-018-0129-z

[…] Materials and methods section). We identified, using MIDAS with a cut-off of p < 0.05, 963 genes with alternative splicing events (Fig. ). As a second method to analyze alternative splicing, we used ANOSVA with a cut-off of p < 0.01 and found 2,095 genes with alternative splicing events (Fig. ). As a third method, we used FIRMA with a cut-off of p < 0.001 and found 1,402 genes with alternative sp […]


Biyuanling suppresses the toluene 2, 4 diisocyanate induced allergic rhinitis in guinea pigs

PMCID: 5849159
PMID: 29560095
DOI: 10.18632/oncotarget.23039

[…] The results were expressed as means ± SD and analyzed by one-way ANOSVA. Statistical significance was defined at P < 0.05. […]


Splice variants as novel targets in pancreatic ductal adenocarcinoma

Sci Rep
PMCID: 5462735
PMID: 28592875
DOI: 10.1038/s41598-017-03354-z

[…] tion, the differential splicing analysis was conducted using limma. Alternatively spliced probe-sets were identified using a double threshold of adjusted p-value < 1e-06 and absolute log2 FC > 2. The ANalysis Of Splice VAriation (ANOSVA) method was also used as an additional filter with an adjusted p-value < 1e-06 at both the probe and probe-set levels. Only protein-coding genes were finally selec […]


A random effects model for the identification of differential splicing (REIDS) using exon and HTA arrays

BMC Bioinformatics
PMCID: 5445373
PMID: 28545391
DOI: 10.1186/s12859-017-1687-8

[…] lizes the exon level expression intensities by their corresponding gene level intensities, and compares these normalized intensities between sample groups. Another ANOVA based method is the so-called Analysis Of Splice VAriation (ANOSVA) [], which fits a linear model to the observed data aiming to identify non-zero interaction terms between the sample groups and the exons. However, it has been arg […]


An atlas of mouse CD4+ T cell transcriptomes

Biol Direct
PMCID: 4384382
PMID: 25886751
DOI: 10.1186/s13062-015-0045-x

[…] lorations of these data and we anticipate that our data will generally be valuable in the inference of TF activities as well as in the creation of regulatory networks. Finally, I could not follow the analysis of splice variation. The authors say that the major isoform comprises 80-90% of the total expression FOR EACH protein-coding gene. Are they really saying this is true for ALL genes? The legen […]


Algorithms for differential splicing detection using exon arrays: a comparative assessment

BMC Genomics
PMCID: 4391533
PMID: 27391904
DOI: 10.1186/s12864-015-1322-x
call_split See protocol

[…] erlying assumption in PAC is the proportionality of exon expression to its corresponding gene expression. Deviation from exon to gene expression results in low correlation and therefore indicates DS. ANOSVA detects DS by applying statistical tests to the parameters of a fitted exon expression model. SplicingCompass, originally developed for NGS data, can easily be adapted to exon array data. The i […]

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ANOSVA institution(s)
Affymetrix, Inc, 3380 Central Expressway, Santa Clara, CA, USA
ANOSVA funding source(s)
Affymetrix, Inc., Santa Clara, CA, USA; Pasteur Institute, Paris, France; Roche, Inc., Palo Alto, CA, USA; University of Rochester Medical Center, Rochester, NY, USA; Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA, USA

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