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PCRP / Protein Capture Reagents Program
Generates protein affinity reagents to a large number of human transcription factors. PCRP consists of three core centers: antigen production, traditional monoclonal antibody (mAb) production, and recombinant phage displayed antibody binding fragment (rAb) production. It has produced a combined total of over 1,500 rAbs and mAbs. The database was designed to establish and test high-throughput methods which offers the advantages of comprehensiveness, uniform protocols and reduced cost.
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Provides germ-line V genes from the immunoglobulin (Ig) loci of human and mouse. VBASE2 is an integrative database that contains Ig germline V genes from the heavy chain and lambda and kappa light chain loci of human and mouse. It connects several separated data collections and thud combines all V gene annotation and classification data from the distinct resources. The program DNAPLOT, for analysis and visualization of the expressed immune repertoire of an organism, is included in VBASE2.
Provides open, user-friendly access to detailed data on the rapidly growing list of HIV broadly neutralizing antibodies (bNAbs), including neutralization profiles, sequences and three-dimensional structures (when available). It also provides an extensive list of visualization and analysis tools, such as heatmaps to analyse neutralization data as well as structure and sequence viewers to correlate bNAbs properties with structural and sequence features of individual antibodies. The goal of the bNAber database is to enable researchers in this field to easily compare and analyse available information on bNAbs thereby supporting efforts to design an effective vaccine for HIV/AIDS.
A searchable database which ranks antibodies by the number of times they have been cited. This allows researchers to easily find antibodies that have been used in peer-reviewed publications and the accompanying citations are listed, so users can check the data contained within the publications. This makes CiteAb a useful resource for identifying antibodies for experiments and also for finding information to demonstrate antibody validation. The database currently contains more than 2.5 million antibodies. In addition to searching, users can also browse through the antibodies and add their own publications to the CiteAb database.
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