Unlock your biological data
The determination of epitopes targeted by antibodies is useful for understanding virus escape, antibody optimization and epitope-based design of vaccines. Structure determination of antibody–antigen complexes can provide epitope information at the atomic level, but in many instances, atomic-level complex structures can be challenging to obtain. Additional experimental methods for epitope delineation are also available, although they are characterized with lower accuracy and typically require substantial experimental effort. Computational methods for epitope prediction have traditionally aimed at predicting antigen residues that could be part of any antibody epitope, and are thus not antibody specific. More recently, computational methods for antibody-specific epitope prediction (the prediction of the epitope targeted by an antibody of interest) have been developed.
(Chuang et al., 2014) NEP: web server for epitope prediction based on antibody neutralization of viral strains with diverse sequences. Nucleic Acids Res.