Antigen databases | Immunology system data analysis
Human and animal health is threatened by various diseases every day. Acquired as a result of pathogenic microbial agents, infectious diseases are still a major source of mortality throughout the world, contributing to 26% of global mortality in 2001. Of these mortalities, 90% are caused by illnesses such as acute respiratory infections, diarrheal diseases, malaria, AIDS, tuberculosis and measles. Cancer, allergy and many other diseases also cause significant mortality and morbidity in human and animal victims.
Provides information about the mimicry proteins and peptides of both host (and model) and pathogen. miPepBase is a resource that includes the names of host and pathogen proteins, sequences of mimicry peptide, autoimmune disease caused due to mimicry peptide, gene ontology information of the protein, PDB ID of the structure of protein, or type of immunological response generated by mimicry peptide.
Assists researchers in designing and discovering suitable epitopes/antigens for cancer vaccine/immunotherapy. This workbench takes full advantage of genomic data generated from cancer cell lines over the years.
Gathers information about human leukocyte antigen (HLA) response-type of influenza type A. Flutope is a database which compiles data for all strains resulted from a study investigating the influence of HLA genotype heterogeneity on possible cytotoxic T-lymphocyte (CTL) response to over 180 influenza H1N1 genomes. Data is organized by epitope set, multiscale data et HLA profile variation and allows to browse results by strains or by ethnic groups.
Emphasizes the particularities of known E. coli serogroups and facilitates the identification of common epitopes. ECODAB is an online resource containing collection of E. coli O-antigen structures, polymerase and flippase amino acid sequences. It stores the amino acid sequence of each newly added glycosyltransferases (GT). Moreover, users can search sequences from other bacteria in this database.
Generates protein affinity reagents to a large number of human transcription factors. PCRP consists of three core centers: antigen production, traditional monoclonal antibody (mAb) production, and recombinant phage displayed antibody binding fragment (rAb) production. It has produced a combined total of over 1,500 rAbs and mAbs. The database was designed to establish and test high-throughput methods which offers the advantages of comprehensiveness, uniform protocols and reduced cost.
A database that combines antigenic data of flaviviruses, specialized analysis tools, and workflows for automated complex analyses focusing on applications in immunology and vaccinology. FLAVIdB represents a new generation of databases in which data and tools are integrated into a data mining infrastructures specifically designed to aid rational vaccine design by discovery of vaccine targets.