High blood pressure has now become a major global health concern. Angiotensin converting enzyme (ACE) seems to be responsable of the increasing of blood pressure by converting the inactive angiotensin I (decapeptide) to the active angiotensin II (octapeptide), which is a potent vasoconstrictor hormone that controls blood pressure. Besides some chemical drugs, diet and lifestyle also can play a significant role in the prevention of high blood pressure. In the past, small bioactive peptides with antihypertensive activity have been discovered. Since many of these peptides are part of proteins present in our food, these are not considered toxic and may represent a new strategy for the prevention and treatment of hypertension. Hence, there is a substantial interest in discovering peptides with antihypertensive, e.g. natural food, algae, fungi, microorganisms, and insects.
(Kumar et al., 2015) AHTPDB: a comprehensive platform for analysis and presentation of antihypertensive peptides. Nucleic Acids Res.