High blood pressure has now become a major global health concern. Angiotensin converting enzyme (ACE) seems to be responsable of the increasing of blood pressure by converting the inactive angiotensin I (decapeptide) to the active angiotensin II (octapeptide), which is a potent vasoconstrictor hormone that controls blood pressure. Besides some chemical drugs, diet and lifestyle also can play a significant role in the prevention of high blood pressure. In the past, small bioactive peptides with antihypertensive activity have been discovered. Since many of these peptides are part of proteins present in our food, these are not considered toxic and may represent a new strategy for the prevention and treatment of hypertension. Hence, there is a substantial interest in discovering peptides with antihypertensive, e.g. natural food, algae, fungi, microorganisms, and insects.
A manually curated database of experimentally validated antihypertensive peptides. Information pertaining to peptides with antihypertensive activity was collected from research articles and from various peptide repositories. It is anticipated that AHTPDB will be a useful and unique resource for the researchers working in the field of antihypertensive peptides.
The food sources available and the antihypertensive peptide sequences tailored from them by a number of ways, characterized by different methods and ACE inhibition quantitated by various assays are increasing day by day in volume and details. ACEpepDB aims to provide comprehensive information on these various aspects of food derived antihypertensive peptides that are available in literature.
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