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ANTs specifications


Unique identifier OMICS_15671
Name ANTs
Alternative name Advanced Normalization Tools
Software type Toolkit/Suite
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages C++
Computer skills Advanced
Stability Stable
Insight ToolKit
Maintained Yes




No version available



  • person_outline Brian Avants

Publication for Advanced Normalization Tools

ANTs citations


Repeated mild traumatic brain injury can cause acute neurologic impairment without overt structural damage in juvenile rats

PLoS One
PMCID: 5940222
PMID: 29738554
DOI: 10.1371/journal.pone.0197187

[…] eneity in T2*-weighted images was corrected by estimating the bias field with N4 Bias Correction [] and template images generated for sham, single and repeated injury cohorts at each time point using Advanced Normalization Tools (ANTs,[]. The resulting template images were then combined using ANTs into a study-specific template [,] that was segmented into different t […]


Impulsivity in Parkinson’s Disease Is Associated With Alterations in Affective and Sensorimotor Striatal Networks

PMCID: 5932175
PMID: 29755401
DOI: 10.3389/fneur.2018.00279
call_split See protocol

[…] oftware.htm)]. None of the patients showed head motion (translation and rotation about each of the axes) greater than 3 mm during the experiment.Functional connectivity MRI data were normalized using Advanced Normalization Tools v2.1.0 rc3 [ANTs ()], following a multistep approach in which we (1) preprocessed the T1-weighted image, (2) calculated the warp parameters from the T1-weighted image to a […]


Analysis of neuroanatomical differences in mice with genetically modified serotonin transporters assessed by structural magnetic resonance imaging

Mol Autism
PMCID: 5894125
PMID: 29651330
DOI: 10.1186/s13229-018-0210-z
call_split See protocol

[…] e appropriate transform and averaged to create a population atlas representing the average anatomy of the study sample. All registrations were performed with a combination of mni_autoreg tools [] and advanced normalization tools (ANTs) [, ]. The result of the registration is to have all the scans deformed into alignment with each other in an unbiased fashion. This allows for the analysis of the de […]


A Statistically Representative Atlas for Mapping Neuronal Circuits in the Drosophila Adult Brain

Front Neuroinform
PMCID: 5876320
PMID: 29628885
DOI: 10.3389/fninf.2018.00013

[…] Group-wise intensity templates were constructed with the Advanced Normalization Tools (ANTs) software (Avants et al., ), using an algorithm building an average shaped brain that follows a two-step strategy. First, the intensity images of all brains used for […]


Amygdala–medial prefrontal cortex connectivity relates to stress and mental health in early childhood

PMCID: 5928403
PMID: 29522160
DOI: 10.1093/scan/nsy017

[…] sed framework for flexibly integrating neuroimaging analysis tools (). The software packages used in this preprocessing pipeline included FMRIB Software Library (FSL v5.0.8; ), FreeSurfer (v5.3.0; ), Advanced Normalization Tools (ANTs v2.1.0; ) and Nipype’s implementation of Artifact Detection Tools (ART; realignment and slice timing cor […]


Focusing on the Differences of Resting State Brain Networks, Using a Data Driven Approach to Explore the Functional Neuroimaging Characteristics of Extraversion Trait

Front Neurosci
PMCID: 5844978
PMID: 29556171
DOI: 10.3389/fnins.2018.00109
call_split See protocol

[…] d Xing, ), and submitted into the recon-all routine in FreeSurfer 5.1 to extract the brain tissues, (2) all individual anatomical brain images were transformed into the MNI152 standard space by using Advanced Normalization Tools (ANTs, (Avants and Gee, ). […]


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ANTs institution(s)
Penn Image Computing and Science Laboratory, University of Pennsylvania, Philadelphia, PA, USA
ANTs funding source(s)
This work was supported by Grant R01EB006266-01 and by K01-ES025432-01 from the National Institute Of Biomedical Imaging and Bioengineering and administered through the UCLA Center for Computational Biology.

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