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APSampler specifications


Unique identifier OMICS_04023
Name APSampler
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages C, C++, Perl
License MIT License
Computer skills Advanced
Stability Stable
Maintained Yes


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Publication for APSampler

APSampler citations


Combinations of Genetic Variants Occurring Exclusively in Patients

PMCID: 5367802
PMID: 28377798
DOI: 10.1016/j.csbj.2017.03.001

[…] , , . a study including thousands of patients with breast cancer and control participants revealed no significant interactions among 2.5 billion possible two-snp combinations . using an algorithm, apsampler , combinations of up to five genetic variants have been analyzed in studies of multiple sclerosis , . and in networks of genetic variants, combinations of several genetic variants […]


Variants of the Coagulation and Inflammation Genes Are Replicably Associated with Myocardial Infarction and Epistatically Interact in Russians

PMCID: 4675542
PMID: 26658659
DOI: 10.1371/journal.pone.0144190

[…] by pcr. no inconsistencies were observed., deviations of the observed genotype frequencies from hardy-weinberg equilibrium and haplotype analysis were studied with haploview 4.2 software., the apsampler algorithm [] was used to identify the alleles, genotypes and their combinations, whose carriage is associated with mi. the findings were then validated by standard statistical approaches: […]


The CXCR2 Gene Polymorphism Is Associated with Stroke in Patients with Essential Hypertension

PMCID: 4662298
PMID: 26648969
DOI: 10.1159/000441529

[…] to estimate the differences between allele and genotype frequency distribution in the study groups. the association between allele and/or genotype combinations and the risk of stroke was analyzed by apsampler 3.6.0; the program and its description are available at https://code.google.com/p/apsampler (common algorithm has been described elsewhere []). to adjust for multiple testing, we used […]


Three allele combinations associated with Multiple Sclerosis

PMCID: 1557481
PMID: 16872485
DOI: 10.1186/1471-2350-7-63

[…] on the use of standard enumerational methodologies. in a recent paper [], we described a novel algorithm based on markov chain monte carlo exploration using a bayesian statistical basis, apsampler, which allows the exploration of genotypes tied to phenotypic trait levels to identify possible combinations of allelic variants at multiple loci that could affect disease development. […]

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APSampler institution(s)
Bioinformatics Laboratory, GosNIIGenetika, Moscow, Russia

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