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ARB specifications


Unique identifier OMICS_06762
Name ARB
Alternative name Average Relative Binding
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes

Publication for Average Relative Binding

ARB citations


Evolutionary Analysis and Prediction of Peptide Vaccine Candidates for Foot and Mouth Disease Virus Types A and O in Bangladesh

Evol Bioinform Online
PMCID: 4219755
PMID: 25452681
DOI: 10.4137/EBO.S17027
call_split See protocol

[…] k/ipd/mhc/bola), and based on that data, alleles were selected for MHC-I prediction. ProPred-I is a web-based tool that predicts binding peptides for MHC class-I alleles. IEDB analysis resource using Average Relative Binding (ARB) was utilized to predict IC50 values for peptides binding to specific MHC molecules. The peptides that have IC50 value less than 500 nm are considered as binders and thos […]


Designing Peptide Based HIV Vaccine for Chinese

Biomed Res Int
PMCID: 4106118
PMID: 25136573
DOI: 10.1155/2014/272950
call_split See protocol

[…] on binding affinity between HLA DR types and HIV epitopes. These methods included Consensus method [], NN-align (netMHCII-2.2) [], stabilization matrix alignment method (SMM-align) [], Sturniolo [], average relative binding (ARB) [], NetMHCIIpan [], and Combinatorial library (ComLib) []. […]


Residue analysis of a CTL epitope of SARS CoV spike protein by IFN gamma production and bioinformatics prediction

BMC Immunol
PMCID: 3575293
PMID: 22963340
DOI: 10.1186/1471-2172-13-50

[…] s; S: Spike protein; SFU: Spot forming unit; FACS: Fluorescence activated cell sorter; CTL: Cytotoxic lymphocyte; BFA: Brefeldin A; ANN: Artificial neural network; SMM: Stabilized matrix method; ARB: Average relative binding. […]


Association of HLA alleles with Plasmodium falciparum severity in Malian children

Tissue Antigens
PMCID: 3152196
PMID: 21447146
DOI: 10.1111/j.1399-0039.2011.01661.x

[…] edicted high to medium binding affinity [500 IC50 (nM) or less] for HLA-A*30:01, HLA-A*30:02 and HLA-A*33:01 were identified with the Average Neural Networks (ANN), Stabilized Matrix Method (SMM) and Average Relative Binding (ARB) algorithms –. The algorithms were accessed on the Immune Epitope Database (IEDB) and Analysis Resource website ( The amino acid seq […]


HLA Class I Restriction as a Possible Driving Force for Chikungunya Evolution

PLoS One
PMCID: 2829075
PMID: 20195467
DOI: 10.1371/journal.pone.0009291

[…] 2, *4403, *4501, *4601, *4801, *5101, *5301, *5401, *5701 and *5801) was performed using two online computational systems available in the Immune Epitope Database Analysis Resource (IEDB-AR) , namely Average Relative Binding (ARB) matrix and Artificial Neural Network (ANN). The ARB system is based upon a matrix of coefficients derived from the association of each of the 20 amino acids at each poss […]


Helper T Cell Epitope Mapping Reveals MHC Peptide Binding Affinities That Correlate with T Helper Cell Responses to Pneumococcal Surface Protein A

PLoS One
PMCID: 2828482
PMID: 20195541
DOI: 10.1371/journal.pone.0009432
call_split See protocol

[…], and MHCPred ( external software(s) were used to predict peptide binding affinities to mouse I-A and I-E as well as HLA-DR, -DP and -DQ. In brief, for average relative binding (ARB) evaluation, 10-fold cross validation results stored at IEDB were used to estimate performance. Because the binding of peptides to MHC class II molecules is not dependent […]


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ARB institution(s)
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, San Diego, CA, USA

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