Offers assembly and gene annotation of Ascaris suum also known as large roundworm of pigs, which is in the Ascarididae family. The database reports the 273 megabase draft genome of Ascaris suum and compares it with other nematode genomes. This genome has low repeat content (4.4%) and encodes about 18,500 protein-coding genes. The A. suum secretome (about 750 molecules) is rich in peptidases linked to the penetration and degradation of host tissues, and an assemblage of molecules likely to modulate or evade host immune responses. This genome provides a comprehensive resource to the scientific community and underpins the development of urgently needed interventions (drugs, vaccines and diagnostic tests) against ascariasis and other nematodiases.
Faculty of Veterinary Science, The University of Melbourne, Parkville, Victoria, Australia; BGI-Shenzhen, Shenzhen, China; Ontario Institute for Cancer Research, MaRS Centre, South Tower, Toronto, ON, Canada; Laboratory of Parasitology and Parasitic Diseases, University of Ghent, Merelbeke, Belgium; California Institute of Technology, Pasadena, CA, USA; Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, New South Wales, Australia; Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark
Ascaris suum funding source(s)
Supported by the Australian Research Council, by a Victorian Life Sciences Computation Initiative (grant number VR0007) on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government, by the Australian Academy of Science, the Australian-American Fulbright Commission, Melbourne Water Corporation, and by the IBM Research Collaboratory for Life Sciences.