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ASD specifications


Unique identifier OMICS_02672
Name ASD
Alternative name AlloSteric Database
Restrictions to use None
Version 3.0
Maintained Yes


  • person_outline Jian Zhang

Publications for AlloSteric Database

ASD citations


Structure based Markov random field model for representing evolutionary constraints on functional sites

BMC Bioinformatics
PMCID: 4765150
PMID: 26911566
DOI: 10.1186/s12859-016-0948-2

[…] from the literature according to homology. For the CSA data set, the proteins with five or more catalytic sites annotated in the literature were collected. The second data set was collected from the AlloSteric Database (ASD) [], which annotates allosteric sites from the literature. For the ASD data set, the proteins with five or more annotated allosteric sites were collected. The third data set w […]


The Structural Basis of ATP as an Allosteric Modulator

PLoS Comput Biol
PMCID: 4161293
PMID: 25211773
DOI: 10.1371/journal.pcbi.1003831

[…] To recapitulate the family profile of allosteric proteins, a phylogenetic tree was built from the ATP allosteric database. A multiple sequence alignment (MSA) was performed by a ‘progressive algorithm’ using ClustalX and BLOSUM 30 matrix . MEGA 5.0 was used to build the phylogenetic tree from the MS […]


Rational Engineering of Enzyme Allosteric Regulation through Sequence Evolution Analysis

PLoS Comput Biol
PMCID: 3395594
PMID: 22807670
DOI: 10.1371/journal.pcbi.1002612

[…] atasets. First, we constructed annotated catalytic and allosteric sites collected from hand-curated databases. The catalytic site atlas (CSA) contains experimentally confirmed catalytic sites and the allosteric database (ASD) has manually curated allosteric sites with at least three cases of experimental evidences in 3D structure or biochemistry , . We found 56 allosteric proteins that have both c […]


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ASD institution(s)
Department of Pathophysiology, Shanghai Jiao-Tong University School of Medicine, Shanghai, China
ASD funding source(s)
National Basic Research Program of China (973 Program) [2015CB910403, in part]; National Natural Science Foundation of China [81322046, 81473137, 81302698, in part]; Shanghai Rising-Star Program [13QA1402300, in part]; Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning and the Program for New Century Excellent Talents in University [NCET-12-0355, in part]

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