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|Alternative name||AlloSteric Database|
|Restrictions to use||None|
- person_outline Jian Zhang
Publications for AlloSteric Database
Structure based Markov random field model for representing evolutionary constraints on functional sites
[…] from the literature according to homology. For the CSA data set, the proteins with five or more catalytic sites annotated in the literature were collected. The second data set was collected from the AlloSteric Database (ASD) , which annotates allosteric sites from the literature. For the ASD data set, the proteins with five or more annotated allosteric sites were collected. The third data set w […]
The Structural Basis of ATP as an Allosteric Modulator
[…] To recapitulate the family profile of allosteric proteins, a phylogenetic tree was built from the ATP allosteric database. A multiple sequence alignment (MSA) was performed by a ‘progressive algorithm’ using ClustalX and BLOSUM 30 matrix . MEGA 5.0 was used to build the phylogenetic tree from the MS […]
Rational Engineering of Enzyme Allosteric Regulation through Sequence Evolution Analysis
[…] atasets. First, we constructed annotated catalytic and allosteric sites collected from hand-curated databases. The catalytic site atlas (CSA) contains experimentally confirmed catalytic sites and the allosteric database (ASD) has manually curated allosteric sites with at least three cases of experimental evidences in 3D structure or biochemistry , . We found 56 allosteric proteins that have both c […]
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