To investigate the role of tissue-specific variation of allele-specific methylation (ASM) in the human brain and its relation to allelic biases in whole blood, we examined ASM across multiple brain regions and matched blood samples collected from multiple donors. Our data shows that although a large proportion of ASM is conserved across tissues, there are specific differences in the extent and distribution of ASM sites between regions of the brain and whole blood. Genome browser tracks displaying ASM signals as well as an online tool plotting ASM for sites of interest are available for download from a searchable database.
Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Department of Psychological Sciences, Birkbeck, University of London, London, UK; University of Exeter Medical School, University of Exeter, Exeter, UK; School of Biological Sciences, University of Essex, Colchester, UK
ASMBrainBlood funding source(s)
The UK Medical Research Council (MRC) (grant number MR/K013807/1); US National Institutes of Health (grant number AG036039); the EU-FP7 project EpiTrain (REA grant agreement n° 316758)