Autoantigen databases | Immunology system data analysis
Autoantibodies (AAb) are antibodies that bind to individual's own antigens. Their production can be affected by genetic predisposition, environment, viruses and pathogens (via epitope mimicking) and chemicals, etc.
Collects published raw datasets obtained from serum profiling assays on proteome microarrays. AAgMarker is a database that provides a toolbox for mining these data. This resource has collected high-throughput auto-antibody (IgG) profiling of 12 diseases. It also provides advanced search enabling users to set their parameters for identification of biomarkers, and includes biomarkers identified from literature.
A database using text-mining and manual curation. AAgAtlas contains 45 830 autoantigen-related abstracts and 94 313 sentences extracted from PubMed using the keywords of either ‘autoantigen’ or ‘autoantibody’ or their lexical variants, which were further refined to 25 520 abstracts, 43 253 sentences and 3984 candidates by the bio-entity recognizer based on the Protein Ontology. 1126 genes as human autoantigens and 1071 related human diseases are identified, with which a human autoantigen database was constructed.