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The autoimmune diseases result from a dysfunction of the immune system due to which elements of the organism (cells, tissues or whole organs) are subjected to immune attack by agents of its own immune system. The immune response is complicated and entails numerous, different and complex mechanisms of control and regulation; still, its core discriminative power stems from the specificity of the antigen–antibody interaction. Most of the classified autoimmune diseases target nervous tissue, but the cumulative prevalence lies with endocrine system, which is implicated in more high-prevalence autoimmune syndromes.
(Gkantouna et al., 2015) Introducing dAUTObase: a first step towards the global scale geoepidemiology of autoimmune syndromes and diseases. Bioinformatics.