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B-cell epitopes (or, antibody epitopes) can be defined as regions on molecules that are specifically bound by B-cell receptors (antibodies). They can include native protein structures, linear peptides, carbohydrates and other biological macromolecules. The majority of short linear peptides have the potential to be B-cell epitopes (Blythe et al., 2005; Greenbaum et al., 2007).
(Blythe et al., 2005) Benchmarking B cell epitope prediction: underperformance of existing methods. Protein Sci.
(Greenbaum et al., 2007) Towards a consensus on datasets and evaluation metrics for developing B-cell epitope prediction tools. J. Mol. Recognit.
(Zhang et al., 2008) Immune epitope database analysis resource (IEDB-AR). Nucleic Acids Res.