Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 95
Release date: Jun 30 2016
Last update date: Aug 9 2018
Access: Public
Diseases: Psoriasis
Dataset link Pathologic Immune Pathways in Psoriasis are Rapidly Attenuated by Tofacitinib Treatment: A Randomized Phase 2 Study in Patients with Moderate to Severe Psoriasis

Experimental Protocol


Twelve patients with plaque psoriasis were randomized (3:1) to receive tofacitinib 10 mg or placebo twice daily for 12 weeks. Biopsies were taken from lesional and non-lesional skin at baseline, and from lesional skin on Day 1, Day 3, and Weeks 1, 2, 4 and 12. Biopsies were examined for psoriatic epidermal features (thickness; Ki67+ keratinocytes, keratin 16 [KRT16] mRNA expression; phosphoSTAT [pSTAT] + nuclei) and T-cell and dendritic cell (DC) subsets using immunohistochemistry. mRNA transcripts were quantified by microarray.

Repositories


GEO

GSE69967

ArrayExpress

E-GEOD-69967

BioProject

PRJNA287287

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Contact


Mayte Suarez-Farinas