Computational protocol: Comparison of Effects of Botulinum Toxin Injection Between Subacute and Chronic Stroke Patients

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Protocol publication

[…] The sample size was calculated based on standardized effect sizes obtained from previously published data from patients with brain lesions. Power analysis was performed using the G∗Power software version 3.1 (University of Dusseldorf, Dusseldorf, Germany). We expected only small numbers of chronic stroke patients to be undergoing rehabilitation, and a priori analysis with the Mann-Whitney U test indicated that a sample size of at least 8 patients in each group would provide a statistical power of 80% (β = 0.20 and α = 0.05). Taking into account the 10% dropout rate, a total of 18 patients were needed.Statistical analysis was performed using SPSS version 22.0 (SPSS Inc., Chicago, IL). Baseline characteristics between the 2 groups were compared with the Mann–Whitney U test for continuous variables and with Fisher exact test for categorical variables. Changes within each group were analyzed with the Wilcoxon signed-rank test. Comparisons between the 2 groups at each time-point were performed by the Mann–Whitney U test. A P value <0.05 was considered statistically significant. […]

Pipeline specifications

Software tools G*Power, SPSS
Application Miscellaneous
Organisms Homo sapiens
Diseases Contracture, Stroke