|Dataset type:||Expression profiling by array|
|Number of samples:||6|
|Release date:||Feb 15 2019|
|Last update date:||Feb 16 2019|
|Dataset link||Ectopic expression of DNA methyltransferases DNMT3A2 and DNMT3L leads to aberrant hypermethylation and postnatal lethality in mice|
We generated transgenic mice expressing both DNMT3A2 and DNMT3L ectopically in broad somatic cells throughout the lifetime (DNMTs-Tg mice). All DNMTs-Tg mice showed delayed postnatal growth and finally died within 20 weeks after birth. We hypothesized that the exogenous DNMT3A2 and DNMT3L abnormally methylated some genes to produce these severe phenotypes. As DNA methylation generally silences gene expression, we conducted comprehensive gene expression analyses in heart tissues of DNMTs-Tg mice to identify genes that were abnormally hypermethylated by exogenous DNMT3A2 and DNMT3L.