|Number of samples:||6|
|Release date:||Feb 16 2018|
|Last update date:||Nov 30 2018|
|Diseases:||Heart Failure, Cardiomyopathies, Acute Kidney Injury|
|Dataset link||Increased Susceptibility to AKI in a Mouse Model of Presymptomatic Cardiomyopathy|
mRNA profiles were generated by performing RNA-seq on adult kidney tissue from transgenic mice (FVB/N mice that overexpress CryAB containing the R120G missense mutation driven by the cardiomyocyte-specific α-myosin heavy chain promoter. We performed analysis in triplicate of kidneys from transgenic animals (prior to the onset of heart failure) vs. age-matched, sex-matched (male) control mice by deep sequencing using Illumina Hi-Seq 2500.