Computational protocol: Acute single channel EEG predictors of cognitive function after stroke

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Protocol publication

[…] After obtaining informed consent, the National Institute of Health Stroke Scale (NIHSS; []) and Modified Rankin Scale [mRS; ] were completed at hospital bedside within 72 hours of stroke symptom onset to document the extent of stroke-related neurological deficits and global disability, respectively. With both instruments, higher scores reflect poorer outcome. The Oxfordshire Community Stroke Project Classification [] was used to classify stroke into four categories: Total Anterior Circulation Stroke, Partial Anterior Circulation Stroke, Posterior Circulation Stroke and Lacunar Stroke. A family member of the patient completed the Short Form of the Informant Questionnaire on Cognitive Decline in the Elderly (Short-IQCODE), to rule out the presence of pre-morbid dementia [].Continuous EEG was obtained at hospital bedside within 72 hours of stroke symptom onset. The single electrode was placed at FP1 according to the International 10–20 system, using 10% divisions of the inion-to-nasion distance. After minimising signal impedance, participants were asked to close their eyes and relax for the 3-min recording session. At 90-days post-stroke, participants were administered the MoCA at a location of their convenience. All study instruments were administered by AA following specialist training with experienced clinicians. For their participation, patients received $10 gift vouchers. This research was approved by Australian Catholic University and South Eastern Sydney Local Health District Human Research Ethics Committees, and each participant (or their carer/substitute decision maker) provided written informed consent for voluntary participation.Previous research examining the effectiveness of DAR in predicting 90-day cognitive functioning in stroke patients [] reported a significant correlation equivalent to a large effect size (d = 0.66; []). Sample size calculations in the current study were based on the conservative assumption that the single channel EEG device might produce a smaller effect. Power calculations computed using G*Power 3.1.7 [] identified that with a one-sided alpha level of 0.05 and power of 85%, the current planned correlational analysis required a total sample size of 19 participants to detect a relationship equating to a large (d = 0.55) effect. [...] Grand averaged RP values were compared with published age-based normative data [] using independent samples t-tests. Pearson product-moment correlations were computed between 90-day MoCA Total Scores and neurophysiological (i.e. delta, theta, alpha, beta, DAR, DTR), neurological (i.e. NIHSS, mRS,) and demographic (i.e. age, years of education) data collected within the first 72 hours after admission. Statistically significant variables were entered into hierarchical linear regression analyses to explore the combination of neurological measures, demographic characteristics, and neurophysiological data that best predicted 90-day cognitive outcomes. All analyses were completed with IBM SPSS Statistics for Windows, version 23 (IBM Corp., Armonk, N.Y). […]

Pipeline specifications

Software tools G*Power, SPSS
Application Miscellaneous
Organisms Homo sapiens