Dataset features

Specifications


Application: RNA-seq analysis
Number of samples: 33
Release date: Nov 17 2018
Last update date: Nov 29 2018
Access: Public
Diseases: Spondylitis, Ankylosing, Arthritis, Psoriatic
Genes: IL17A, IL22, IL23A, SFTPA2
Taxon: Homo sapiens
Dataset link RORγt inhibition selectively targets IL-17 producing human iNKT and γδ-T cells enriched in Spondyloarthritis while preserving IL-22 responses

Experimental Protocol


iNKT (CD3+TCRVb11+6B11+), γδ-T (CD3+TCRγδ+) cells and Tconv (CD3+CD161-; negative for iNKT and γδ-T markers) cells were sorted from peripheral blood samples of SpA patients (n=7) and RA patients (n=5). Sequence-libraries of each sample were sequenced on a NextSeq500 system (Illumina).

Repositories


GEO

GSE122624

ENA

SRP169085

BioProject

PRJNA505801

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Contact


Koen Venken
Liesbet Martens