Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 16
Release date: Dec 31 2011
Last update date: Jul 10 2014
Access: Public
Diseases: Hypoplastic Left Heart Syndrome
Dataset link Identifying gene expression profiles in hypoplastic left heart syndrome and age-matched normal controls

Experimental Protocol


Myocardial samples were isolated from the RV of 6 HLHS neonates, diagnosed based upon clinical features including hypoplasia/atresia of the ascending aorta, various degrees of underdevelopment of the aortic valve, mitral valve, and LV cavity, and retrograde flow in the aortic arch as determined by conventional 2-D echocardiography. The mean gestational age at birth of all subjects was 38 weeks (range 36-39) and the mean body weight at surgery of 2.7 kg (range 2.1-3.4 kg) (3 males, 3 females). All subjects were undergoing stage 1 Norwood reconstruction. Children with HLHS and other complex cardiac anomalies entailing non-HLHS single ventricle circulation were excluded from our study. For control samples, RV and LV myocardial tissue was obtained from 5 newborns aged between 1-28 days (mean 18 days; 3 males and 2 females) with normal cardiac anatomy and expired from non-cardiac diseases processes.

Repositories


GEO

GSE23959

ArrayExpress

E-GEOD-23959

BioProject

PRJNA130383

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Contact


Marco Ricci