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The Illumina HumanMethylation450 BeadChip is increasingly utilized in epigenome-wide association studies, however, this array-based measurement of DNA methylation is subject to measurement variation. Appropriate data preprocessing to remove background noise is important for detecting the small changes that may be associated with disease.
(Xu et al., 2016) ENmix: a novel background correction method for Illumina HumanMethylation450 BeadChip. Nucleic Acids Res.