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In imaging MALDI- MS, spatial information and protein expression can be created. However, data from imaging MALDI-MS spectra require considerable signal processing to generate quantitative results and to provide input to later classification algorithms. To compare MALDI-MS spectra at different spatial locations (sample-to- sample comparisons) or classify parts of the spectra, a processing step called baseline correction is essential.
(Williams., 2005) An algorithm for baseline correction of MALDI mass spectra. Proceedings of the 43nd Annual Southeast Regional Conference.