Computational protocol: The N-terminus of mature human frataxin is intrinsically unfolded

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Protocol publication

[…] Eukaryotic frataxin sequences were retrieved by a BLASTp search ( [] and aligned using Clustal X version 2.0 ( []. Intrinsically unfolded regions were predicted using the DISEMBL ( [] and PONDR ( [] web servers. Chemical shift analysis was carried out using the CSI (chemical shift indices) ( [] and RCI (random coil index) ( [] web servers. […]

Pipeline specifications

Software tools BLASTP, Clustal W, DisEMBL, RCI
Application Protein structure analysis
Organisms Homo sapiens
Diseases Friedreich Ataxia, Heredodegenerative Disorders, Nervous System
Chemicals Iron