Computational protocol: Thymidylate synthase gene (TYMS) polymorphisms in sporadic and hereditary breast cancer

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Protocol publication

[…] The statistical analyze between HBC and SBC groups was calculated using the Chi-square test Yates corrected and the Fisher Exact test through the software Statistical Package for Social Sciences v.17.0 (version 17, SPSS Inc., Chicago, IL) []. Associations between polymorphisms in the 5’-UTR region of TYMS and BC risk were obtained through the Odds Ratios (ORs) was calculated, considering a 95% confidence interval (CI) and p-values less to 0.05. HardyWeinberg imbalance has been evaluated for the three groups using the program HAPLOVIEW[].According to G*power 3.1.2 software, to a power of 80% in the analyses, we need, respectively, 52 and 56 subjects, to Fisher Exact test and Chi-square test. […]

Pipeline specifications

Software tools GATK, Haploview, G*Power
Applications Miscellaneous, GWAS
Organisms Homo sapiens
Diseases Breast Neoplasms, Genetic Diseases, Inborn