A method for the secondary structure determination and fold recognition from protein circular dichroism spectra. BeStSel allows structural biologists to solve the secondary structure of their protein samples accurately and to gain more structural information. The versatile algorithm presents a significant improvement compared with existing ones. With fast CD spectral data acquisition and accurate structure determination, our algorithm provides biophysical scientists with a powerful tool.
Department of Biochemistry and MTA-ELTE NAP B Neuroimmunology Research Group, Institute of Biology, Eötvös Loránd University, Budapest, Hungary; DISCO Beamline, Synchrotron SOLEIL, Gif-sur-Yvette, France; Division of Protein Structural Biology, Institute for Protein Research, Osaka University, Osaka, Japan
BeStSel funding source(s)
This work was supported by the Hungarian Scientific Research Fund (K81950) and KTIA_NAP_13-2-2014-0017. SRCD measurements were supported by SOLEIL (Proposals 20140646, 20130475, 20120589, 201110054, and 20110405).