Computational protocol: Association between mitochondrial DNA variations and schizophrenia in the northern Chinese Han population

Similar protocols

Protocol publication

[…] The purified PCR products were sequenced by ABI 377 DNA automatic sequencer. Sample sequences were validated twice with Sequencher 4.1.4 software (Gene Codes Corp, Ann Arbor, MI, USA) to ensure accuracy of the data set. The sequences then were aligned and compared with rCRS []. The mtDNA haplogroups were classified according to the mtDNA Build16 (19 February 2014) using MitoTool []. Differences between the control and patient groups were ascertained using SPSS PASW Statistics v. 18.0 (IBM, Chicago, IL). The significance threshold for the haplogroup tests was 0.0020 (0.05/25); 0.0022 (0.05/22) for females and 0.0021 (0.05/24) for males []. Power analysis was conducted by PS program [] statistical software. […]

Pipeline specifications

Software tools Sequencher, MitoTool, SPSS
Applications Miscellaneous, Phylogenetics
Organisms Homo sapiens