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Bi-Targeting specifications


Unique identifier OMICS_14638
Name Bi-Targeting
Software type Package/Module
Interface Command line interface
Restrictions to use None
Input data miRNA sequences and mRNA sequences
Operating system Unix/Linux
Programming languages Java
Computer skills Advanced
Stability Stable
Maintained Yes


No version available


  • person_outline Michal Ziv-Ukelson <>

Publication for Bi-Targeting

Bi-Targeting citations


Plasmodium P36 determines host cell receptor usage during sporozoite invasion

PMCID: 5470872
PMID: 28506360
DOI: 10.7554/eLife.25903.022

[…] entry, suggesting that it may represent a relevant target in both p. falciparum and p. vivax. the understanding of host-parasite interactions may also contribute to novel therapeutic approaches. sr-bi-targeting agents have entered clinical development for prevention of hcv graft infection (). our data suggest that sr-bi-targeting strategies may be effective to prevent establishment of the liver […]


Targeting SR BI for Cancer Diagnostics, Imaging and Therapy

PMCID: 5037127
PMID: 27729859
DOI: 10.3389/fphar.2016.00326

[…] sr-bi+ cancer cell cytotoxicity versus free drug with the added benefit, as reported by , of diminishing undesired cytotoxicity against cells with limited sr-bi expression. interestingly, this sr-bi-targeting strategy was also extended to the encapsulation and delivery of the hydrophilic drug, doxorubicin (), wherein the efficient (>70%) loading of drug within rhdl halved its ic50 […]


Proceedings of the 13th annual conference of INEBRIA

PMCID: 5032602
PMID: 27654147
DOI: 10.1186/s13722-016-0062-9

[…] (2 vs. 41). however, there was no significant difference in the overall costs ($4266 vs. $4150, p = 0.916) or rates (6.8 vs. 6.5 p = 0.838) associated with all ed presentations., conclusions: a bi targeting aod use by adolescents and facilitating their access to aod services can have lasting impacts on their health outcomes as assessed in terms of ed events related to aod consumption. […]


Bioinformatic tools for microRNA dissection

PMCID: 4705652
PMID: 26578605
DOI: 10.1093/nar/gkv1221

[…] vir-mir db () predicts viral mirna candidate hairpins. it has examined 2266 available viral genome sequences for putative mirna hairpins and identified 33 691 hairpin candidates in 1491 genomes. bi-targeting () is an algorithm that identifies groups of viral and host mirnas that cooperate in post-transcriptional gene regulation, and their target genes that are involved in similar biological […]


A Biomimic Reconstituted High Density Lipoprotein Based Drug and p53 Gene Co delivery System for Effective Antiangiogenesis Therapy of Bladder Cancer

PMCID: 4536251
PMID: 26156217
DOI: 10.1186/s11671-015-0965-5

[…] cancer therapy via synergistic mechanism., in this study, a biomimic reconstituted high-density-lipoprotein-based drug and p53 gene co-delivery system (rhdl/cd-pei/p53 complexes) based on sr-bi targeting delivery and combined tumor therapy strategy was successfully constructed for simultaneously tumor-targeted delivery of cd and p53 gene. combined cd and p53 gene therapy using a biomimic […]


Hepatitis C Virus Cell Cell Transmission and Resistance to Direct Acting Antiviral Agents

PMCID: 4022730
PMID: 24830295
DOI: 10.1371/journal.ppat.1004128

[…] study elegantly demonstrated that hcv can lose sr-bi-dependence for cell-cell spread . together with the findings observed for sr-bi-specific mab nk-8h5-e3, our data demonstrate that defined sr-bi-targeting compounds appear to have a lower genetic barrier for resistance than other hteis such as cldn1-targeting compounds. this may be due to the fact that cldn1 is an essential factor […]

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Bi-Targeting institution(s)
Department of Computer Science, Ben-Gurion University, Beer-Sheva, Israel; Virology and Developmental Genetics/Health Sciences, Ben-Gurion University, Beer-Sheva, Israel

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