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BIC specifications


Unique identifier OMICS_03980
Name BIC
Alternative name Breast cancer Information Core
Restrictions to use None
Maintained Yes


  • Primates
    • Homo sapiens

Publication for Breast cancer Information Core

BIC citations


Targeted next generation sequencing identifies functionally deleterious germline mutations in novel genes in early onset/familial prostate cancer

PLoS Genet
PMCID: 5919682
PMID: 29659569
DOI: 10.1371/journal.pgen.1007355
call_split See protocol

[…] likely not pathogenic, of no clinical significance or of little clinical significance, according to public databases, namely ClinVar (, accessed in January, 2017), Breast Cancer Information Core [BIC (, accessed in January, 2017)], and InSiGHT (via the Leiden Open-source Variation Database [LOVD (, […]


Double Heterozygosity for BRCA1 Pathogenic Variant and BRCA2 Polymorphic Stop Codon K3326X: A Case Report in a Southern Italian Family

Int J Mol Sci
PMCID: 5796231
PMID: 29346284
DOI: 10.3390/ijms19010285

[…] by melanoma, as previously described [,].Each identified variant was investigated in its potential pathogenic role using prediction algorithms such as SIFT and Polyphen, and web databases such as the Breast Cancer Information Core (, COSMIC (, Leiden Open Variation Database (, dbSNP ( […]


Combined annotation‚Äźdependent depletion score for BRCA1/2 variants in patients with breast and/or ovarian cancer

Cancer Sci
PMCID: 5797818
PMID: 29215753
DOI: 10.1111/cas.13464

[…] r, these 5 categories unfortunately confound the clinical direction of the patients.There are several online database resources that provide some interpretation of BRCA sequence variants, such as The Breast Cancer Information Core (BIC), Human Variome Project, or ClinVar. We referred each variant to ClinVar as a standard reporting database recommended by The American College of Medical Genetics. A […]


Evaluating the associations between human circadian rhythms and dysregulated genes in liver cancer cells

PMCID: 5727601
PMID: 29250165
DOI: 10.3892/ol.2017.7109

[…] including Pathway Commons (), Biological General Repository for interaction Datasets (BioGRID) (), Human Protein Reference Database (), ConsensusPathDB (), Database of Interacting Proteins () and the Breast Cancer Information Core and Michigan Molecular Interactions (), and identified to be involved in circadian rhythms. Only the connected component of these 71 seed networks were considered for st […]


Comparison of Ion Personal Genome Machine Platforms for the Detection of Variants in BRCA1 and BRCA2

PMCID: 5784618
PMID: 28392550
DOI: 10.4143/crt.2017.062

[…] 3 for BRCA2. The variants were described as recommended by the Human Genome Variation Society (HGVS) nomenclature ( characterization of the variants was made primarily by Breast Cancer Information Core (BIC) from National Human Genome Institute (, Short Genetic Variations database (dbSNP, […]


Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next generation cancer panel testing

Genet Med
PMCID: 4985612
PMID: 26681312
DOI: 10.1038/gim.2015.166
call_split See protocol

[…] include the Exome Sequencing Project, SIFT, PolyPhen2, MutationTaster, splice site prediction model BDGP, NetGene2, Softberry, Human Gene Mutation Database, and locus-specific databases including the Breast Cancer Information Core and InSiGHT.Evidence supporting benign classification of a variant included, but was not limited to, silent variants without evidence of splicing defects; published func […]


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BIC institution(s)
Unit of Genetic Epidemiology, International Agency for Research on Cancer, Lyon, France

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