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BID specifications


Unique identifier OMICS_15558
Name BID
Alternative name Binding Interface Database
Restrictions to use None
Database management system MySQL
Community driven No
Data access Browse
User data submission Allowed
Maintained No


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Publication for Binding Interface Database

BID citations


Predicting hot spots in protein interfaces based on protrusion index, pseudo hydrophobicity and electron ion interaction pseudopotential features

PMCID: 4951271
PMID: 26934646
DOI: 10.18632/oncotarget.7695

[…] in residues to alanine within a protein interface. A database collecting a list of hot spots identified by alanine scanning mutagenesis experiments is Alanine Scanning Energetics Database (ASEdb) []. Binding Interface Database (BID) is another database which contains experimentally verified hot spots from literature studies [].The characteristics of hot spots have been extensively studied. Sequent […]


Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein Protein Interactions

PMCID: 4518475
PMID: 26091166
DOI: 10.1016/j.chembiol.2015.04.019

[…] entifying hotspot regions at protein surfaces (), commonly assessed by their ability to recapitulate experimental data from sources such as the ASEdb alanine scanning energetics database (), the BID (Binding Interface Database) (), and the HotSprint database (). The first class of methods is empirical and correlates experimental data with surface properties such as protein curvature, electrostatic […]


Hot Spots in a Network of Functional Sites

PLoS One
PMCID: 3759471
PMID: 24023934
DOI: 10.1371/journal.pone.0074320

[…] g the interacting sites from the rest of the structure.Experimental data regarding the binding energies for a limited number of complexes is available mainly by Alanine Scanning Database (ASEdb) and Binding Interface Database (BID) . To complement experimental studies, computational methods are constantly being developed; using energy contribution , , , sequence , , , and structure , , , , , ba […]


A semi supervised boosting SVM for predicting hot spots at protein protein Interfaces

BMC Syst Biol
PMCID: 3521187
PMID: 23282146
DOI: 10.1186/1752-0509-6-S2-S6

[…] (ΔΔG). Owing to the high cost and low efficiency of this traditional experimental method, public databases of experimental results such as the Alanine Scanning Energetics Database (ASEdb) [] and the Binding Interface Database (BID) [] contain only a limited number of complexes.Some works focused on the characteristics of hot spot due to its critical role. Studies on the composition of hot spots a […]


A feature based approach to modeling protein–protein interaction hot spots

Nucleic Acids Res
PMCID: 2677884
PMID: 19273533
DOI: 10.1093/nar/gkp132

[…] chine (SVM), and tested with 10-fold cross-validation. Apart from these data, an independent test set, composed of 127 alanine-mutated interface residues in 18 complexes, is also constructed from the Binding Interface Database (BID; () to further validate our predictive models. Comparison of our models with other methods such as alanine scanning methods [Robetta (), FOLDEF […]


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BID institution(s)
Department of Biochemistry & Biophysics, Texas A&M University, TX, USA
BID funding source(s)
Supported by the NSF trought funding from a Biological Informatics Starter Grant DBI-0202599.

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