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big-Pi predictor | Prediction of potential GPI-modification sites in proprotein sequences


Evaluates the degree of presence of the C-terminal sequence signal in a query proprotein sequence based on sequence properties extracted from a learning set. big-Pi predictor allows large-scale database searches for potentially Glycosylphosphatidylinositol (GPI)-anchored protein. It predicts GPI modification sites in precursor sequences. The software integrates terms evaluating amino acid type preferences at given motif positions but also terms judging the conservation of physical properties in the query sequence which represent correlation between few or many motif positions.

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big-Pi predictor classification

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European Molecular Biology Laboratory, Heidelberg, Germany; Max-Delbrück-Centrum für Molekulare Medizin, Berlin-Buch, Germany; Research Institute of Molecular Pathology, Vienna, Austria

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