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BIGMAC specifications


Unique identifier OMICS_11496
Software type Package/Module
Interface Command line interface
Restrictions to use None
Input data Inputs to BIGMAC include assembled contigs from HGAP and the original raw reads with adapters removed.
Biological technology Pacific Biosciences
Operating system Unix/Linux
Computer skills Advanced
Stability Stable
Maintained Yes


No version available



  • person_outline Satish Rao

Publication for BIGMAC

BIGMAC citations


Single molecule sequencing guided scaffolding and correction of draft assemblies

BMC Genomics
PMCID: 5731603
PMID: 29244003
DOI: 10.1186/s12864-017-4271-8

[…] in theory be applied to any extant genome to improve quality. We demonstrate this on both bacterial and yeast genomes using currently available SMS data.To the best of our knowledge, the framework of BIGMAC [] is the most similar to ours. BIGMAC, however, is designed to improve genome accuracy for metagenomic assembly by extensively relying on the assembly itself. As a result, it can hardly correc […]


Underestimating Calorie Content When Healthy Foods Are Present: An Averaging Effect or a Reference Dependent Anchoring Effect?

PLoS One
PMCID: 3743811
PMID: 23967216
DOI: 10.1371/journal.pone.0071475

[…] and the actual calorie content of these is likely to be very low (e.g. a 40 g portion of carrot contains 59 kcal and a 40 g portion of celery contains 13 kcal) by comparison with a burger (McDonalds BigMac –550 kcal), making any veridical assessments hard to detect.A further replication of the current study that would be of considerable interest is in exploring whether calorie estimates accuratel […]


The effects of serum lipids on the in vitro activity of lumefantrine and atovaquone against Plasmodium falciparum

Malar J
PMCID: 3426466
PMID: 22640826
DOI: 10.1186/1475-2875-11-177

[…] Blood (20 mL) was taken from three healthy volunteer subjects (N = 3) after an overnight fast and also at 2 and 4 hours after consuming a meal containing more than 50g fat (a Mac Donald’s BigMac and a tall portion of French fries). Blood samples were centrifuged at 800 g for 5 minutes. Serum was collected, inactivated at 56°C in a water bath and kept at 30°C until use. Triglyceride lev […]


A Novel Classification of Lung Cancer into Molecular Subtypes

PLoS One
PMCID: 3283716
PMID: 22363766
DOI: 10.1371/journal.pone.0031906

[…] e would be lung tumors containing the EGFR exon 19 mutation for which commercial assays and targeted agents are currently available. The latest version of this model can be found online here:>.The online version contains additional in-depth information about relevant genes, genetic tests, pathways, drugs, targets, […]


Several RNase T2 enzymes function in induced tRNA and rRNA turnover in the ciliate Tetrahymena

Mol Biol Cell
PMCID: 3248902
PMID: 22049026
DOI: 10.1091/mbc.E11-08-0689

[…] of the cytosol was observed in any strain background. Of interest, DAPI staining revealed that cells undergoing depletion of Rnt2 A had enlarged macronuclei that correlated with increased cell size (BigMac phenotype; ). DAPI staining of cells undergoing depletion of Rnt2 B instead showed an apparent increase in the number of micronuclei in many of the cells (MultiMic phenotype; ). T. thermophila […]


Impact of Early Growth on Postprandial Responses in Later Life

PLoS One
PMCID: 3164134
PMID: 21904606
DOI: 10.1371/journal.pone.0024070

[…] utrient composition of the dietary guidelines and included 52% energy as carbohydrate, 14% energy as protein and 34% energy as fat (REC-meal) on a separate day. The commercial FF-meal consisted of a BigMac hamburger, french fries and light cola. Both test meals contained the same amount of energy (∼3400 kJ = ∼800 kcal). The foodstuffs and the nutrient composition of the study meals are shown in . […]


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BIGMAC institution(s)
Department of Electrical Engineering and Computer Sciences, UC Berkeley, Berkeley, USA; Pacific Biosciences, Menlo Park, USA; Joint Genome Institute, Walnut Creek, USA

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