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|Interface||Command line interface|
|Restrictions to use||None|
|Input data||Inputs to BIGMAC include assembled contigs from HGAP and the original raw reads with adapters removed.|
|Biological technology||Pacific Biosciences|
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- person_outline Satish Rao
Publication for BIGMAC
Single molecule sequencing guided scaffolding and correction of draft assemblies
[…] in theory be applied to any extant genome to improve quality. We demonstrate this on both bacterial and yeast genomes using currently available SMS data.To the best of our knowledge, the framework of BIGMAC  is the most similar to ours. BIGMAC, however, is designed to improve genome accuracy for metagenomic assembly by extensively relying on the assembly itself. As a result, it can hardly correc […]
Underestimating Calorie Content When Healthy Foods Are Present: An Averaging Effect or a Reference Dependent Anchoring Effect?
[…] and the actual calorie content of these is likely to be very low (e.g. a 40 g portion of carrot contains 59 kcal and a 40 g portion of celery contains 13 kcal) by comparison with a burger (McDonalds BigMac –550 kcal), making any veridical assessments hard to detect.A further replication of the current study that would be of considerable interest is in exploring whether calorie estimates accuratel […]
The effects of serum lipids on the in vitro activity of lumefantrine and atovaquone against Plasmodium falciparum
[…] Blood (20 mL) was taken from three healthy volunteer subjects (N = 3) after an overnight fast and also at 2 and 4 hours after consuming a meal containing more than 50g fat (a Mac Donald’s BigMac and a tall portion of French fries). Blood samples were centrifuged at 800 g for 5 minutes. Serum was collected, inactivated at 56°C in a water bath and kept at 30°C until use. Triglyceride lev […]
A Novel Classification of Lung Cancer into Molecular Subtypes
[…] e would be lung tumors containing the EGFR exon 19 mutation for which commercial assays and targeted agents are currently available. The latest version of this model can be found online here:
Several RNase T2 enzymes function in induced tRNA and rRNA turnover in the ciliate Tetrahymena
[…] of the cytosol was observed in any strain background. Of interest, DAPI staining revealed that cells undergoing depletion of Rnt2 A had enlarged macronuclei that correlated with increased cell size (BigMac phenotype; ). DAPI staining of cells undergoing depletion of Rnt2 B instead showed an apparent increase in the number of micronuclei in many of the cells (MultiMic phenotype; ). T. thermophila […]
Impact of Early Growth on Postprandial Responses in Later Life
[…] utrient composition of the dietary guidelines and included 52% energy as carbohydrate, 14% energy as protein and 34% energy as fat (REC-meal) on a separate day. The commercial FF-meal consisted of a BigMac hamburger, french fries and light cola. Both test meals contained the same amount of energy (∼3400 kJ = ∼800 kcal). The foodstuffs and the nutrient composition of the study meals are shown in . […]
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