A next generation sequencing (NGS) mapping and alignment algorithm customized to process mate pair library sequencing. Mate Pair sequencing is a comprehensive and cost effective method for detecting structural variants throughout the entire genome. BIMA was developed to handle sequencing artifact inherent in mate pair library preparation (biotin junction reads, paired-end read contamination, chimeras, etc.).
Department of Information Technology, MN, USA; Department of Molecular Medicine, Department of Laboratory Medicine and Pathology and Department of Biomedical Statistics and Informatics, Mayo Clinic, Chinahester, MN, USA