Footprinting protein functional surfaces by comparative spatial patterns. fPOP provides the spatial patterns of protein binding sites including both holo and apo forms from more than 40,000 structures. This database provides an easily accessible resource for studying functional surfaces, assessing conformational changes between bound and unbound forms and analyzing functional divergence.
A database of predicted multiple, possibly overlapping, protein-protein interaction (PPI). JET2 Viewer reports putative protein binding sites for all three-dimensional (3D) structures available in the Protein Data Bank (PDB). This knowledge base was generated by applying the computational method JET2 at large-scale on more than 20,000 chains. JET2 strategy yields very precise predictions of interacting surfaces and unravels their evolutionary process and complexity. JET2 Viewer provides an online intelligent display, including interactive 3D visualization of the binding sites mapped onto PDB structures and suitable files recording JET2 analyses. Predictions were evaluated on more than 15,000 experimentally characterized protein interfaces. The data can be used to foster new strategies for PPI modulation and interaction surface redesign.