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Protocols

Bioblocks specifications

Information


Unique identifier OMICS_25120
Name Bioblocks
Software type Package/Module
Interface Web user interface
Restrictions to use None
Input format CSV
Output data Bioblocks generates multiple outputs. The first output is a translation of the protocol to machine-readable code for its automated execution on a compatible hardware platform. The second output is a natural language translation of the protocol to aid in verification. The last output is the representation of the protocol as a workflow using Cytoscape.
Output format JSON, PNG, TXT
Computer skills Basic
Version 28.1
Stability Stable
Maintained No

Maintainer


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Information


Unique identifier OMICS_25120
Name Bioblocks
Software type Application/Script
Interface Command line interface
Restrictions to use None
Input format CSV
Output data Bioblocks generates multiple outputs. The first output is a translation of the protocol to machine-readable code for its automated execution on a compatible hardware platform. The second output is a natural language translation of the protocol to aid in verification. The last output is the representation of the protocol as a workflow using Cytoscape.
Output format JSON, PNG, TXT
Programming languages Javascript
Computer skills Advanced
Version 1.0
Stability Stable
Maintained No

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Publication for Bioblocks

Bioblocks citations

 (20)
library_books

A Potential Compensatory Role of Panx3 in the VNO of a Panx1 Knock Out Mouse Model

2018
PMCID: 5946002
PMID: 29780304
DOI: 10.3389/fnmol.2018.00135

[…] sphate (ATP, pH-buffered, Sigma-Aldrich), 50 mM and 140 mM potassium gluconate (KGlu, Sigma-Aldrich). Blockers used include; 50 μM carbenoxolone (CBX, Sigma-Aldrich), 100 nM mefloquine (MFQ, QU024-1, BioBlocks), 10 μM brilliant blue food dye (BB FCF, Sigma Aldrich). It is important to note that all blocking data were collected after incubation for 5 min before application of 140 mM KGlu and EtBr, […]

library_books

Pannexin 1 sustains the electrophysiological responsiveness of retinal ganglion cells

2018
Sci Rep
PMCID: 5895610
PMID: 29643381
DOI: 10.1038/s41598-018-23894-2

[…]  K+, 0.1 mM ATP), and lower Ca2+ (0.5 mM) concentrations (all from Sigma). For specific inhibition of Panx1-mediated currents, 100 µM of 10panx1 peptide (Anaspec, Fremont, CA), 50 nM mefloquine (MFQ; Bioblocks, San Diego, CA), 25 µM water-soluble carbenoxolone (CBX, Invitrogen), or 300 µM water-soluble probenecid (Thermo Fisher Scientific) were added to the external solution according to Ma et al. […]

library_books

Construction and in vivo assembly of a catalytically proficient and hyperthermostable de novo enzyme

2017
Nat Commun
PMCID: 5572459
PMID: 28842561
DOI: 10.1038/s41467-017-00541-4

[…] cal mechanism. We therefore anticipate that the descendants of this de novo designed enzyme will act as cheap, green, and catalytically proficient catalysts for industrial biotechnology and versatile bioblocks for synthetic biology, while providing insight into the rules underpinning the engineering of natural and designed enzymes. […]

call_split

Glial pannexin1 contributes to tactile hypersensitivity in a mouse model of orofacial pain

2016
Sci Rep
PMCID: 5133615
PMID: 27910899
DOI: 10.1038/srep38266
call_split See protocol

[…] ce that induced a withdrawal response in 8 of 10 trials. Tactile responses were assessed before and on 1–4 weeks post CFA or saline injection. The effects of a Panx1 channel blocker, mefloquine (MFQ, Bioblocks #QU024-1; 10 mg/kg body weight, i.p. injected 2 hours before behavior testing) were investigated at 1, 3, and 4 weeks after CFA injection in wildtype (WT: Panx1+/+) mice.We also performed a […]

call_split

P2X7R Panx1 Complex Impairs Bone Mechanosignaling under High Glucose Levels Associated with Type 1 Diabetes

2016
PLoS One
PMCID: 4861344
PMID: 27159053
DOI: 10.1371/journal.pone.0155107
call_split See protocol

[…] nction, cells were pretreated with the P2X7R blockers A438079 hydrochloride (10 μM; TOCRIS bioscience, Bristol, United Kingdom) [, ], A740003 (10 μM; TOCRIS) [, ] and mefloquine (MFQ, 100nM; QU024-1, Bioblocks, San Diego, CA) [] in flow media for 15 min prior to OFSS and during 5 min of OFSS. […]

library_books

A small fish model for behavioral toxicological screening of new antimalarial drugs: a comparison between erythro and threo mefloquine

2015
BMC Res Notes
PMCID: 4386100
PMID: 25886204
DOI: 10.1186/s13104-015-1088-x

[…] re toxic effects as compared to erythro-mefloquine.These finding seem to be consistent with in-vitro studies. For instance, Iglesias et al. [] have demonstrated, that erythro-mefloquine (specifically Bioblocks QU024-1) reduced the magnitude of Pannexin-1 currents at a much lower dose than did threo-mefloquine (specifically Bioblocks QU025-1). Pannexin-1 is a trans-membrane protein that connects th […]

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Bioblocks institution(s)
Departamento de Inteligencia Artificial, Universidad Politécnica de Madrid, Campus de Montegancedo, Madrid, Spain
Bioblocks funding source(s)
This work was funded by EU FP7FET-Proactive Project, EVOPROG grant, the Spanish National Projects TIN2012-36992 and TIN2016-81079-R.

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